Research Themes

The Sonenberg Lab is interested in the study of eukaryotic mRNA translation, including the fundamental mechanisms governing translation, its role in normal physiology, and its dysregulation in disease. We are particularly interested in how mRNA translation is regulated in the context of cancer, innate immunity, learning and memory, and development.

Our lab utilizes a variety of experimental techniques including classical biochemistry, proteomics, ribosome profiling, CRISPR and RNAi, as well as behavioural tests using in vivo mouse models. Click on a research theme below to learn more.