Recent Publications

Mehdi Hooshmandi, David Ho-Tieng, Kevin C Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky (2025). Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice. Mol Autism. doi: 10.1186/s13229-025-00648-2

Xiaozhuo Ran, Bell Xi Wu, Venkatasubramanian Vidhyasagar, Lifang Song, Xu Zhang, Reese Jalal Ladak, Mona Teng, Wail Ba-Alawi, Vivek Philip, Housheng H He, Nahum Sonenberg, Benjamin H Lok (2025). PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer. Nat Commun. doi: 10.1038/s41467-025-57257

Gary Loughran, Dmitry E Andreev, Ilya M Terenin, Olivier Namy, Martin Mikl, Martina M Yordanova, C Joel Mcmanus, Andrew E Firth, John F Atkins, Christopher S Fraser, Zoya Ignatova, Shintaro Iwasaki, Joanna Kufel, Ola Larsson, Sebastian A Leidel, Alexander S Mankin, Marco Mariotti, Marvin E Tanenbaum, Ivan Topisirovic, Nora Vázquez-Laslop, Gabriela Viero, Neva Caliskan, Yiwen Chen, Patricia L Clark, Jonathan D Dinman, Philip J Farabaugh, Wendy V Gilbert, Pavel Ivanov, Jeffrey S Kieft, Oliver Mühlemann, Matthew S Sachs, Ivan N Shatsky, Nahum Sonenberg, Anna-Lena Steckelberg, Anne E Willis, Michael T Woodside, Leos Shivaya Valasek, Sergey E Dmitriev, Pavel V Baranov (2025). Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR). Nat Struc Mol Bio. doi: 10.1038/s41594-025-01492.

Cristiano Ferrario, John Mackey, Karen A Gelmon, Nathalie Levasseur, Poul H Sorensen, Htoo Zarni Oo, Gian L Negri, Veronica WL Tse, Sandra E Spencer, Grace Cheng, Gregg B Morin, Sonia Del Rincon, Tiziana Cotechini, Christophe Gonçalves, Charles CT Hindmarch, Wilson H Miller Jr, Mehdi Amiri, Tayebeh Basiri, Victor Villareal-Corpuz, Sam Sperry, Kevin Gregorczyk, Gonzalo Spera, Nahum Sonenberg, Michael Pollak (2025). Phase Ib pharmacodynamic study of the MNK inhibitor Tomivosertib (eFT508) combined with paclitaxel in patients with refractory metastatic breast cancer. Clin Cancer Res. doi: 10.1158/1078-0432.CCR-24-0841

Mehdi Amiri, Niaz Mahmood, Soroush Tahmasebi, Nahum Sonenberg (2025). eIF4F-mediated Dysregulation of mRNA Translation in Cancer. RNA. doi: 10.1261/rna.080340.124

Cristiano Ferrario, John Mackey, Karen A Gelmon, Nathalie Levasseur, Poul H Sorensen, Htoo Z Oo, Gian L Negri, Veronica WL Tse, Sandra E Spencer, Grace Cheng, Gregg B Morin, Sonia Del Rincon, Tiziana Cotechini, Christophe Gonçalves, Charles CT Hindmarch, Wilson H Miller, Mehdi Amiri, Tayebeh Basiri, Victor Villareal-Corpuz, Sam Sperry, Kevin Gregorczyk, Gonzalo Spera, Nahum Sonenberg, Michael Pollak (2024). Phase Ib pharmacodynamic study of the MNK inhibitor Tomivosertib (eFT508) combined with paclitaxel in patients with refractory metastatic breast cancer. Clin Cancer Res. doi: 10.1158/1078-0432.CCR-24-0841

Reese Jalal Ladak, Jung-Hyun Choi, Jun Luo, Owen J Chen, Niaz Mahmood, Alexander J He, Parisa Naeli, Patric Harris Snell, Esha Bayani, Huy-Dung Hoang, Tommy Alain, Jose G Teodoro, Jianwei Wang, Xu Zhang, Seyed Mehdi Jafarnejad, Nahum Sonenberg (2024). The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses. PNAS. doi: 10.1073/pnas.2413018121

Ziying Huang, Shane Wiebe, Anmol Nagpal, Junghyun Choi, Caleb Walters, Niaz Mahmood, Arkady Khoutorsky, Jean-Claude Lacaille, Nahum Sonenberg (2024). Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory. Learn Mem. doi: 10.1101/lm.054018.124

Ziying Huang, Shane Wiebe, Laura Marsal-García, Ilse Gantois, Nahum Sonenberg (2024). Strategies for Assessing Autistic-Like Behaviors in Mice. J Vis Exp. doi: 10.3791/66846

Andy Y L Gao, Yanis Inglebert, Roy Shi, Alina Ilie, Jelena Popic, Jamie Mustian, Nahum Sonenberg, John Orlowski, R Anne McKinney (2024). Impaired hippocampal plasticity associated with loss of recycling endosomal SLC9A6/NHE6 is ameliorated by the TrkB agonist 7,8-dihydroxyflavone. Biochim Biophys Acta Mol Basis Dis. doi: 10.1016/j.bbadis.2024.167529

Elva Vidya, Yasaman Jami-Alahmadi, Adarsh K Mayank, Javeria Rizwan, Jia Ming Stella Xu, Tianhao Cheng, Rania Leventis, Nahum Sonenberg, James A Wohlschlegel, Maria Vera, Thomas F Duchaine (2024). EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization. Cell Rep. doi: 10.1016/j.celrep.2024.114781

Natalie M Walker, Yuta Ibuki, A Patrick McLinden, Keizo Misumi, Dylan C Mitchell, Gabriel G Kleer, Alison M Lock, Ragini Vittal, Nahum Sonenberg, Amanda L Garner, Vibha N Lama (2024). MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction. JCI. doi: 10.1172/JCI168393

Peng Wang, Zixian Li, Sung-Hoon Kim, Haijin Xu, Hao Huang, Chutong Yang, Abby Snape, Jung-Hyun Choi, Sara Bermudez, Marie-Noelle Boivin, Nicolas Ferry, Jason Karamchandani, Bhushan Nagar, Nahum Sonenberg (2024). PPM1G dephosphorylates eIF4E in control of mRNA translation and cell proliferation.Life Sci Alliance. doi: 10.26508/lsa.202402755

Ehsan Yazdanpanah Moghadam, Nahum Sonenberg, Muthukumaran Packirisamy (2024). Microfluidic Wound-Healing Assay for Comparative Study on Fluid Dynamic, Chemical and Mechanical Wounding on Microglia BV2 Migration. Micromachines. doi: 10.3390/mi15081004

Niaz Mahmood, Jung-Hyun Choi, Pei You Wu, Sean W. Dooling, Trent A. Watkins, Ziying Huang, Jesse Lipman, Hanjie Zhao, Anqi Yang, Jake Silversmith, Yanis Inglebert, Constantinos Koumenis, Vijendra Sharma, Jean-ClaudeLacaille, Wayne S. Sossin, Arkady Khoutorsky, R. Anne McKinney, Mauro Costa-Mattioli, Nahum Sonenberg (2024). The ISR downstream target ATF4 represses long-term memory in a cell type–specific manner. PNAS. doi: 10.1073/pnas.2407472121

Jung-Hyun Choi, Laura Marsal-García, Eve Peraldi, Caleb Walters, Ziying Huang, Ilse Gantois, Nahum Sonenberg (2024). Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology. PNAS. doi: 10.1073/pnas.2407546121

Jung-Hyun Choi, Jun Luo, Geoffrey G Hesketh, Shuyue Guo, Angelos Pistofidis, Reese Jalal Ladak, Yuxin An, Parisa Naeli, Tommy Alain, T Martin Schmeing, Anne-Claude Gingras, Thomas Duchaine, Xu Zhang, Nahum Sonenberg, Seyed Mehdi Jafarnejad (2024). Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction. Sci Adv. doi: 10.1126/sciadv.adl563

Danielle Cozachenco, Felipe C Ribeiro, Elentina K Argyrousi, Agnieszka Staniszewski, Shane Wiebe, Joao D Calixtro, Rubens Soares-Neto, Aycheh Al-Chami, Fatema El Sayegh, Sara Bermudez, Emily Arsenault, Marcelo Cossenza, Jean-Claude Lacaille, Karim Nader, Hongyu Sun, Fernanda G De Felice, Mychael V Lourenco, Ottavio Arancio, Argel Aguilar-Valles, Nahum Sonenberg, Sergio T Ferreira (2024). The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease. Alzheimers Dement. doi: 10.1002/alz.14034

Roberta Cagnetta, Jean-Claude Lacaille, Nahum Sonenberg (2024). Exploration of new space elicits phosphorylation of GluA1(Ser831) and S6K and expression of Arc in the hippocampus in vivo as in long-term potentiation. Mol Brain. doi: 10.1186/s13041-024-01100-x

Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Mark E Issa, Brendan Cordeiro, Qianyu Guo, Audrey Emond, Mikhael Attias, William Yang, Dany Plourde, Jie Su, Marina Godoy Gimeno, Yao Zhan, Alba Galán, Tomasz Rzymski, Milena Mazan, Magdalena Masiejczyk, Jacek Faber, Elie Khoury, Alexandre Benoit, Natascha Gagnon, David Dankort, Fabrice Journe, Ghanem E Ghanem, Connie M Krawczyk, H Uri Saragovi, Ciriaco A Piccirillo, Nahum Sonenberg, Ivan Topisirovic, Christopher E Rudd, Wilson H Miller, Sonia V Del Rincón (2024).Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. J Clin Invest. doi: 10.1172/JCI181575

Gary Loughran, Dmitry E Andreev, Ilya M Terenin, Olivier Namy, Martin Mikl, Martina M Yordanova, C Joel Mcmanus, Andrew E Firth, John F Atkins, Christopher S Fraser, Zoya Ignatova, Shintaro Iwasaki, Joanna Kufel, Ola Larson, Sebastian A Leidel, Alexander S Mankin, Marco Mariotti, Marvin E Tanenbaum, Ivan Topsirovic, Nora Vázquez-Laslop, Gabriela Viero, Neva Caliskan, Yiwen Chen, Patricia L Clark, Jonathan D Dinman, Philip J Farabaugh, Wendy V Gilbert, Pavel Ivanov, Jeffrey S Kieft, Oliver Mühlemann, Matthew S Sachs, Ivan N Shatsky, Nahum Sonenberg, Anna-Lena Steckelberg, Anne E Willis, Michael T Woodside, Shivaya Leos Valasek, Sergey E Dmitriev, Pavel V Baranov (2024). Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR). HAL. doi: hal-04395528

Mehdi Amiri, Stephen J Kiniry, Anthony P Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R Dufour, Negar Tabatabaei, Qiyun Deng, Michael A Bellucci, Keerthana Harwalkar, Matthew P Stokes, Vincent Giguère, Randal J Kaufman, Yojiro Yamanaka, Pavel V Baranov, Soroush Tahmasebi, Nahum Sonenberg (2024). Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells. Cell Rep. doi: 10.1016/j.celrep.2023.113615

Greco Hernández, Alejandra García, Shira Weingarten-Gabbay, Rishi Kumar Mishra, Tanweer Hussain, Mehdi Amiri, Gabriel Moreno-Hagelsieb, Angélica Montiel-Dávalos, Paul Lasko, Nahum Sonenberg (2023). Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes. NAR. doi: 10.1093/nar/gkad1152

Vijendra Sharma, Mauricio M Oliveira, Rapita Sood, Abdessattar Khlaifia, Danning Lou, Mehdi Hooshmandi, Tzu-Yu Hung, Niaz Mahmood, Maya Reeves, David Ho-Tieng, Noah Cohen, Po-chieh Cheng, Mir Munir A Rahim, Masha Prager-Khoutorsky, Randal J Kaufman, Kobi Rosenblum, Jean-Claude Lacaille, Arkady Khoutorsky, Eric Klann, Nahum Sonenberg (2023). mRNA translation in astrocytes controls hippocampal long-term synaptic plasticity and memory. PNAS. doi: 10.1073/pnas.2308671120

Lauren Pugsley, Sai Kiran Naineni, Mehdi Amiri, Akiko Yanagiya, Regina Cencic, Nahum Sonenberg, Jerry Pelletier (2023). C8ORF88: A Novel eIF4E-Binding Protein. Genes. doi: 10.3390/genes14112076

Eric Krochmalnek, Andrea Accogli, Judith St-Onge, Nassima Addour-Boudrahem, Gyan Prakash, Sung-Hoon Kim, Tristan Brunette-Clement, Ghadd Alhajaj, Lina Mougharbel, Elena Bruneau, Kenneth A Myers, Francois Dubeau, Jason Karamchandani, Jean-Pierre Farmer, Jeffrey Atkinson, Jeffrey Hall, Chantal Chantal Poulin, Bernard Rosenblatt, Joel Lafond-Lapalme, Alexander Weil, Catherine Fallet-Bianco, Steffen Albrecht, Nahum Sonenberg, Jean-Baptiste Riviere, Roy W Dudley, Myriam Srour (2023). mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes. Neurol Genet. doi: 10.1212/NXG.0000000000200103

Calvin Wong, Diana Tavares-Ferreira, Carolina Thörn Perez, Behrang Sharif, Sonali Uttam, Mehdi Amiri, Kevin C Lister, Mehdi Hooshmandi, Vivienne Nguyen, Philippe Séguéla, Nahum Sonenberg, Theodore J Price, Christos G Gkogkas, Arkady Khoutorsky (2023). 4E-BP1–dependent translation in nociceptors controls mechanical hypersensitivity via TRIM32/type I interferon signaling. Sci. Adv. doi: 10.1126/sciadv.adh9603

Roberta Cagnetta, John G Flanagan, Nahum Sonenberg (2023). Control of Selective mRNA Translation in Neuronal Subcellular Compartments in Health and Disease. J Neurosci. doi: 10.1523/JNEUROSCI.2240-22.2023

Jilly F Evans, Francis X McCormack, Nahum Sonenberg, Vera P Krymskaya (2023). Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis. Eur Respir Rev. doi: 10.1183/16000617.0100-2023

Parisa Naeli, Xu Zhang, Patric Harris Snell, Susanta Chatterjee, Muhammad Kamran, Reese Jalal Ladak, Nick Orr, Thomas Duchaine, Nahum Sonenberg, Seyed Mehdi Jafarnejad. (2023) SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression. J. Cell Sci. doi: 10.1242/jcs.261286

Mehdi Hooshmandi, Vijendra Sharma, Carolina Thörn Perez, Rapita Sood, Konstanze Krimbacher, Calvin Wong, Kevin C Lister, Alba Ureña Guzmán, Trevor D Bartley, Cecilia Rocha, Gilles Maussion, Emma Nadler, Patricia Margarita Roque, Ilse Gantois, Jelena Popic, Maxime Lévesque, Randal J Kaufman, Massimo Avoli, Elisenda Sanz, Karim Nader, Randi Jenssen Hagerman, Thomas M Durcan, Mauro Costa-Mattioli, Masha Prager-Khoutorsky, Jean-Claude Lacaille, Veronica Martinez-Cerdeno, Jay R Gibson, Kimberly M Huber, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky (2023). Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron. doi: 10.1016/j.neuron.2023.06.017

Andrea Accogli, Sheng-Jia Lin, Mariasavina Severino, Sung-Hoon Kim, Kevin Huang, Clarissa Rocca, Megan Landsverk, Maha Zaki, Almundher Al-Maawali, Khalid Al-Thihli, G Bradly Schaefer, Monica Davis, Davide Tonduti, Chiara Doneda, Lara M Marten, Chris Mühlhausen, Maria Gomez, Eleonora Lamantea, Rafael Mena, Mathilde Nizon, Vincent Procaccio, Amber Begtrup, Aida Telegrafi, Hong Cui, Heidi L Schulz, Julia Mohr, Saskia Biskup, Mariana Amina Loos, Hilda Verónica Aráoz, Vincenzo Salpietro, Laura Davis Keppen, Manali Chitre, Cassidy Petree, Lucy Raymond, Julie Vogt, Lindsey B Swayer, Alice A Basinger, Signe Vandal Pedersen, Toni S Pearson, Dorothy K Grange, Lokesh Lingapp, Paige McDunnah, Rita Horvath, Benjamin Cogne, Bertrand Isidor, Andreas Hahn, Karen Gripp, Seyed Mehdi Jafarnejad, Elsebet Ostergaard, Carlos E Prada, Daniele Ghezzi, Vykuntaraju K Gowda, Robert W Taylor, Nahum Sonenberg, Henry Houlden, Marie Sissler, Gaurav K Varshney, Reza Maroofian (2023). Clinical, neuroradiological and molecular characterization of mitochondrial threonyl-tRNA-synthetase (TARS2)-related disorder. Genet. Med. doi: 10.1016/j.gim.2023.100938

Alejandra Escós, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz-Ezquerro, Steven C Ley, Ana Cuenda (2023). p38γ and p38δ modulate innate immune response by regulating MEF2D activation. eLife. doi: 10.7554/eLife.86200

Sung-Hoon Kim, Jung-Hyun Choi, Laura Marsal-García, Mehdi Amiri, Akiko Yanagiya, Nahum Sonenberg (2023). The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory. PNAS. doi: 10.1073/pnas.2300008120

Justine R Stehn, Scott R Floyd, Erik W Wilker, H Christian Reinhardt , Scott M Clarke, Qiuying Huang, Roberto D Polakiewicz, Nahum Sonenberg, Yi Wen Kong, Michael B Yaffe (2023). MAPKAP Kinase-2 phosphorylation of PABPC1 controls its interaction with 14-3-3 proteins after DNA damage: A combined kinase and protein array approach. Front Mol Biosci. doi: 0.3389/fmolb.2023.1148933

Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg. (2023) Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP. Mol Brain. doi: 10.1186/s13041-023-00995-2

Erik Storkebaum, Kobi Rosenblum, Nahum Sonenberg. (2023) Messenger RNA Translation Defects in Neurodegenerative Diseases. N Engl J Med. doi: 10.1056/NEJMra2215795

Nahum Sonenberg, Witold Filipowicz. (2023). Recollections: Yasuhiro Furuichi (1940–2022). RNA. doi: 10.1261/rna.079517.122

Ehsan Yazdanpanah Moghadam, Nahum Sonenberg, Muthukumaran Packirisamy (2023). Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration. Biosensors. doi: 10.3390/bios13020290

Jerry Pelletier, Nahum Sonenberg. (2023). Therapeutic targeting of eukaryotic initiation factor (eIF) 4E. Biochem Soc Trans. doi: 10.1042/BST20220285

Mehdi Hooshmandi, Vijen Sharma, Carolina Thorn Perez, Rapita Sood, Konstanze Simbriger, Calvin Wong, Kevin C Lister, Alba Urena Guzman, Trevor D Bartley, Cecilia Rocha, Gilles Maussion, Emma Nadler, Patricia Margarita Roque, Ilse Gantois, Jelena Popic, Maxime Levesque, Randal J Kaufman, Massimo Avoli, Elisenda Sanz, Karim Nader, Randi Jenssen Hagerman, Thomas M Durcan, Mauro Costa-Mattioli, Jean-Claude Lacaille, Veronica Martinez-Cerdeno, Jay R Gibson, Kimberly Huber, Nahum Sonenberg, Christos G Gkogkas, Arkady Khoutorsky. (2023). Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome. BioRxiv. doi: 10.1101/2023.04.24.538123

Felipe Campos Ribeiro, Danielle Cozachenco Ferreira, Fernanda G De Felice, Mychael V Lourenco, Argel Aguilar-Valles, Nahum Sonenberg, Sergio T Ferreira. (2022). Attenuation of translational repression rescues memory impairment in Alzheimers disease mice. Alzheimer's Dement. doi: 10.1002/alz.059761

Phoenix Toboz, Mehdi Amiri, Negar Tabatabaei, Catherine R Dufour, Seung Hyeon Kim, Carine Fillebeen, Charles E Ayemoba, Arkady Khoutorsky, Manfred Nairz, Lijian Shao, Kostandin V Pajcini, Ki-Wook Kim, Vincent Giguère, Regiana L Oliveira, Marco Constante, Manuela M Santos, Carlos R Morales, Kostas Pantopoulos, Nahum Sonenberg, Sandra Pinho, Soroush Tahmasebi. (2022). The amino acid sensor GCN2 controls red blood cell clearance and iron metabolism through regulation of liver macrophages. PNAS. doi: https://www.pnas.org/doi/abs/10.1073/pnas.2121251119

Alejandra Escós, José Martín-Gómez, Diego González-Romero, Ester Díaz-Mora, Rosario Francisco-Velilla, Cesar Santiago, José M Cuezva, Sonia Domínguez-Zorita, Encarnación Martínez-Salas, Nahum Sonenberg, Juan José Sanz-Ezquerro, Seyed Mehdi Jafarnejad, Ana Cuenda. (2022). TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with TPL2 mRNA. PNAS. doi: 10.1073/pnas.2204752119

Zhang Xu, Jung-Hyun Choi, David L Dai, Jun Luo, Reese Jalal Ladak, Qian Li, Yimeng Wang, Christine Zhang, Shane Wiebe, Alex CH Liu, Xiaozhuo Ran, Jiaqi Yang, Parisa Naeli, Aitor Garzia, Lele Zhou, Niaz Mahmood, Qiyun Deng, Mohamed Elaish, Rongtuan Lin, Lara K Mahal, Tom C Hobman, Jerry Pelletier, Tommy Alain, Silvia M Vidal, Thomas Duchaine, Mohammad T Mazhab-Jafari, Xiaojuan Mao, Seyed Mehdi Jafarnejad, Nahum Sonenberg. (2022). SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation. PNAS. doi: 10.1073/pnas.2204539119

Cristiano Ferrario, John Mackey, Karen Gelmon, Poul HB Sorensen, Htoo Zarni Oo, Gregg B Morin, Sonia del Rincon, Mehdi Amiri, Premal Patel, Harvey W Smith, Nahum Sonenberg, Michael N Pollak. (2022). Abstract CT521: Phase 1b trial of the MNK1/2 inhibitor tomivosertib combined with paclitaxel in patients with metastatic breast cancer. Cancer Res. doi: 10.1158/1538-7445.AM2022-CT521

Ioannis D Dimitriou, David Meiri, Yulia Jitkova, Alisha R Elford, Marianne Koritzinsky, Aaron D Schimmer, Pamela S Ohashi, Nahum Sonenberg, Robert Rottapel. (2022). Translational Control by 4E-BP1/2 Suppressor Proteins Regulates Mitochondrial Biosynthesis and Function during CD8+ T Cell Proliferation. J Immunol. doi: 10.4049/jimmunol.2101090

Natasha Saviuk, Yumaine Chong, Peng Wang, Sara Bermudez, Zhe Zhao, Arjun A Bhaskaran, Derek Bowie, Nahum Sonenberg, Ellis Cooper, A Pejmun Haghighi. (2022). Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. Cell Rep. doi: 10.1016/j.celrep.2022.110911

Sara Hegazi, Arthur H Cheng, Joshua J Krupp, Takafumi Tasaki, Jiashu Liu, Daniel A Szulc, Harrod H Ling, Julian Rios Garcia, Shavanie Seecharran, Tayebeh Basiri, Mehdi Amiri, Zobia Anwar, Safa Ahmad, Kamar Nayal, Nahum Sonenberg, Bao-Hua Liu, Hai-Ling Margaret Cheng, Joel D Levine, Hai-Ying Mary Cheng. (2022). UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony. Nat Commun. doi: 10.1038/s41467-022-29244-1

Ana Cuenda, Alejandra Escos, Ester Diaz-Mora, Pilar Fajardo, Diego Gonzalez-Romero, Ana Risco, Jose Martin-Gomez, Eric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Michael Pattison, Juan Jose Sanz-Ezquerro, Steven C Ley. (2022). p38γ and p38δ modulate innate immune response by regulating MEF2D activation. BioRxiv. doi: 10.1101/2022.12.09.519777

Yuri V Svitkin, Anne-Claude Gingras, Nahum Sonenberg. (2022). Membrane-dependent relief of translation elongation arrest on pseudouridine- and N1-methyl-pseudouridine-modified mRNAs. Nucleic Acids Res. doi: 10.1093/nar/gkab1241. (NAR Breakthrough Article)

Jerry Pelletier, Nahum Sonenberg. (2022). Internal Ribosome Entry Sites: Form and Function. Elsevier. doi: 10.1016/B978-0-12-821618-7.00186-3

Alejandra García, Giovanna Maldonado, José L González, Yuri Svitkin, David Cantú, Alejandro García-Carrancá, Nahum Sonenberg, Greco Hernández. High-risk human papillomavirus-18 uses an mRNA sequence to synthesize oncoprotein E6 in tumors. PNAS. doi: 10.1073/pnas.2108359118

Patrick Sénéchal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilène Paquet, Jerry Pelletier. (2021). Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse. CMLS. doi: 10.1007/s00018-021-03940-5

Scott Bell, Vincent McCarty, Huashan Peng, Malvin Jefri, Nuwan Hettige, Lilit Antonyan, Liam Crapper, Liam A O'Leary, Xin Zhang, Ying Zhang, Hanrong Wu, Diane Sutcliffe, Ilaria Kolobova, Thad A Rosenberger, Luc Moquin, Alain Gratton, Jelena Popic, Ilse Gantois, Patrick S Stumpf, Andreas A Schuppert, Naguib Mechawar, Nahum Sonenberg, Michel L Tremblay, Hyder A Jinnah, Carl Ernst. (2021). Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells. Stem Cell Rep. doi: doi.org/10.1016/j.stemcr.2021.06.003

Sujata Jana, Rucha Deo, Rowan P Hough, Yuzhen Liu, Jessie L Horn, Jonathan L Wright, Hung-Ming Lam, Kevin R Webster, Gary G Chiang, Nahum Sonenberg, Andrew C Hsieh. (2022). mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation. JCI Insight. doi: 10.1172/jci.insight.144920

John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P Fahlman, Nika N Danial, D Alan Underhill, Ing Swie Goping. (2021). BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models. Nat Commun. doi: 10.1038/s41467-021-23269-8

John RP Knight, Constantinos Alexandrou, George L Skalka, Nikola Vlahov, Kathryn Pennel, Leah Officer, Ana Teodosio, Georgios Kanellos, David M Gay, Sebastian May-Wilson, Ewan M Smith, Arafath K Najumudeen, Kathryn Gilroy, Rachel A Ridgway, Dustin J Flanagan, Rachael CL Smith, Laura McDonald, Craig MacKay, Anne Cheasty, Kerri McArthur, Emma Stanway, Joshua D Leach, Rene Jackstadt, Joseph A Waldron, Andrew D Campbell, Georgios Vlachogiannis, Nicola Valeri, Kevin M Haigis, Nahum Sonenberg, Christopher G Proud, Neil P Jones, Martin E Swarbrick, Heather J McKinnon, William J Faller, John Le Quesne, Joanne Edwards, Anne E Willis, Martin Bushell, Owen J Sansom. (2021). MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression. Cancer Discov. doi: 10.1158/2159-8290.CD-20-0652

Mehdi Hooshmandi, Vinh Tai Truong, Eviatar Fields, Riya Elizabeth Thomas, Calvin Wong, Vijendra Sharma, Ilse Gantois, Patricia Soriano Roque, Kleanthi Chalkiadaki, Neil Wu, Anindyo Chakraborty, Soroush Tahmasebi, Masha Prager-Khoutorsky, Nahum Sonenberg, Aparna Suvrathan, Alanna J Watt, Christos G Gkogkas, Arkady Khoutorsky. (2021). 4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors. Cell Rep. doi: 10.1016/j.celrep.2021.109036

Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Mark E Issa, Brendan Cordeiro, Qianyu Guo, Audrey Emond, Mikhael Attias, William Yang, Dany Plourde, Jie Su, Marina Godoy Gimeno, Yao Zhan, Alba Galán, Tomasz Rzymski, Milena Mazan, Magdalena Masiejczyk, Jacek Faber, Elie Khoury, Alexandre Benoit, Natascha Gagnon, David Dankort, Fabrice Journe, Ghanem E Ghanem, Connie M Krawczyk, H Uri Saragovi, Ciriaco A Piccirillo, Nahum Sonenberg, Ivan Topisirovic, Christopher E Rudd, Wilson H Miller, Sonia V Del Rincón. (2021). Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses. J Clin Invest. doi: 10.1172/JCI140752

Vijendra Sharma, Rapita Sood, Danning Lou, Tzu-Yu Hung, Maxime Lévesque, Yelin Han, Jeremy Y Levett, Peng Wang, Shravan Murthy, Shannon Tansley, Siyan Wang, Nadeem Siddiqui, Soroush Tahmasebi, Kobi Rosenblum, Massimo Avoli, Jean-Claude Lacaille, Nahum Sonenberg, Arkady Khoutorsky. (2021). 4E-BP2–dependent translation in parvalbumin neurons controls epileptic seizure threshold. PNAS. doi: 10.1073/pnas.2025522118

Valentina Evdokimova, Yuri Svitkin, Nahum Sonenberg. (2021). Alexander Spirin (1931–2020): A visionary scientist, a teacher, a colleague, a friend. PNAS. doi: 10.1073/pnas.2103938118

Xu Zhang, Clément Chapat, Peng Wang, Jung-Hyun Choi, Qian Li, Jun Luo, Shane Wiebe, Sung-Hoon Kim, Nathaniel Robichaud, Isabela Fabri Karam, David Dai, Angela P Hackett, Rongtuan Lin, Tommy Alain, Long Yang, Seyed Mehdi Jafarnejad, Nahum Sonenberg. (2021). microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP. Mol Cell. doi: 10.1016/j.molcel.2021.01.030

Nancy Standart, John Hershey, Michael B Mathews, Nahum Sonenberg. (2021). Richard Jackson (1940–2020)‐A towering presence in translation. EMBO J. doi: 10.15252/embj.2020107551

Jerry Pelletier, T Martin Schmeing, Nahum Sonenberg. (2021). The multifaceted eukaryotic cap structure. WIREs RNA. doi: 10.1002/wrna.1636.

Argel Aguilar-Valles, Danilo De Gregorio, Edna Matta-Camacho, Mohammad J Eslamizade, Abdessattar Khlaifia, Agnieszka Skaleka, Martha Lopez-Canul, Angelica Torres-Berrio, Sara Bermudez, Gareth M Rurak, Stephanie Simard, Natalina Salmaso, Gabriella Gobbi, Jean-Claude Lacaille, Nahum Sonenberg. Antidepressant actions of ketamine engage cell-specific translation via eIF4E. Nature. doi: 10.1038/s41586-020-03047-0

Danilo De Gregorio, Jelena Popic, Justine P Enns, Antonio Inserra, Agnieszka Skalecka, Athanasios Markopoulos, Luca Posa, Martha Lopez-Canul, He Qianzi, Christopher K Lafferty, Jonathan P Britt, Stefano Comai, Argel Aguilar-Valles, Nahum Sonenberg, Gabriella Gobbi. (2021). Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission. PNAS. doi: 10.1073/pnas.202070511

Sung-Hoon Kim, Jung-Hyun Choi, Peng Wang, Christopher D Go, Geoffrey G Hesketh, Anne-Claude Gingras, Seyed Mehdi Jafarnejad, Nahum Sonenberg. (2021). Mitochondrial threonyl-tRNA synthetase TARS2 is required for threonine-sensitive mTORC1 activation. Mol Cell. doi: 10.1016/j.molcel.2020.11.036

Vinay K Mayya, Mathieu N Flamand, Alice M Lambert, Seyed Mehdi Jafarnejad, James A Wohlschlegel, Nahum Sonenberg, Thomas F Duchaine. (2021). microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development. NAR. doi: doi.org/10.1093/nar/gkab162 (NAR Breakthrough Article)

Emily Arsenault, Aisha Asad Ahmed, Ayeila Daneshmend, Zeynep Jihad-Mohamad, Edna Matta-Camacho, Melissa Nyveld, Fatimeh-Frouh Taghavi-Abkuh, Molly Zhang, Nahum Sonenberg, Jean-Claude Lacaille, Argel Aguilar-Valles. (2021). Linking depression, mRNA translation, and serotonin. The Neuroscience of Depression. doi: 10.1016/B978-0-12-817935-2.00009-X

Greco Hernández, Alejandra García, Nahum Sonenberg, Paul Lasko (2020). Unorthodox mechanisms to initiate translation open novel paths for gene expression. JMB. doi: 10.1016/j.jmb.2020.10.035.

Shane Wiebe, Xiang Qi Meng, Sung-Hoon Kim, Xu Zhang, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg (2020). The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior. Mol Autism. doi: 10.1186/s13229-020-00394-7

Shane Wiebe, Anmol Nagpal, Nahum Sonenberg. (2020). Dysregulated translational control in brain disorders: from genes to behavior. Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2020.05.005

Hang Ruan, Xiangyun Li, Xiang Xu, Brian J Leibowitz, Jingshan Tong, Lujia Chen, Luoquan Ao, Wei Xing, Jianhua Luo, Yanping Yu, Robert E Schoen, Nahum Sonenberg, Xinghua Lu, Lin Zhang, Jian Yu (2020) eIF4E S209 phosphorylation licenses myc-and stress-driven oncogenesis. Elife: doi: 10.7554/eLife.60151

Vijendra Sharma, Rapita Sood, Abdessattar Khlaifia, Mohammad Javad Eslamizade, Tzu-Yu Hung, Danning Lou, Azam Asgarihafshejani, Maya Lalzar, Stephen J Kiniry, Matthew P Stokes, Noah Cohen, Alissa J Nelson, Kathryn Abell, Anthony P Possemato, Shunit Gal-Ben-Ari, Vinh T Truong, Peng Wang, Adonis Yiannakas, Fatemeh Saffarzadeh, A Claudio Cuello, Karim Nader, Randal J Kaufman, Mauro Costa-Mattioli, Pavel V Baranov, Albert Quintana, Elisenda Sanz, Arkady Khoutorsky, Jean-Claude Lacaille, Kobi Rosenblum, Nahum Sonenberg (2020). eIF2α controls memory consolidation via excitatory and somatostatin neurons. Nature. doi: 10.1038/s41586-020-2805-8

Amro H Mohammad, Sung-Hoon Kim, Nicholas Bertos, Wissal El-Assaad, Ipshita Nandi, Harvey Smith, Jieyi Yang, Owen J Chen, Isabelle Gamache, Trisha Rao, Bruno Gagnon, Tina Gruosso, Michel L Tremblay, Nahum Sonenberg, Marie-Christine Guiot, William Muller, Morag Park, Jose G Teodoro. Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast CancerPTEN Controls PRR Expression and V–ATPase Activity. Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-20-0088

Jutta Steinberger, Leo Shen, Stephen J. Kiniry, Sai Kiran Naineni, Regina Cencic, Mehdi Amiri, Sarah AE Aboushawareb, Jennifer Chu, Rayelle Itoua Maïga, Brahm J Yachnin, Francis Robert, Nahum Sonenberg, Pavel V Baranov, Jerry Pelletier (2020). Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5′ leader regions. NAR. doi: 10.1093/nar/gkaa662

Jun Zhang, John‐Paul Andersen, Haoran Sun, Xuyun Liu, Nahum Sonenberg, Jia Nie, Yuguang Shi (2020). Aster‐c coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1. EMBO Rep. doi: 10.15252/embr.201949898

Tao Zu, Shu Guo, Olgert Bardhi, Daniel A Ryskamp, Jian Li, Solaleh Khoramian Tusi, Avery Engelbrecht, Kelena Klippel, Paramita Chakrabarty, Lien Nguyen, Todd E Golde, Nahum Sonenberg, Laura PW Ranum (2020). Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice. PNAS. doi: 10.1073/pnas.2005748117

Jennifer E Dawson, Alaji Bah, Zhenfu Zhang, Robert M Vernon, Hong Lin, P Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C Gradinaru, Julie D Forman-Kay (2020). Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition. Nat Commun. doi: 10.1038/s41467-020-16783-8

Fan Huang, Christophe Gonçalves, Margarita Bartish, Joelle Rémy-Sarrazin, Qianyu Guo, Audrey Emond, William Yang, Dany Plourde, Jie Su, Marina Godoy Gimeno, Yao Zhan, Mikhael Attias, Alba Galán, Tomasz Rzymski, Milena Mazan, Magdalena Masiejczyk, Jacek Faber, Elie Khoury, Alexandre Benoit, Natascha Gagnon, David Dankort, Ciriaco A Piccirillo, Fabrice Journe, Ghanem Ghanem, H Uri Saragovi, Nahum Sonenberg, Ivan Topisirovic, Wilson H Miller Jr, Sonia V del Rincón (2020). The MNK1/2-eIF4E axis drives melanoma plasticity, progression, and resistance to immunotherapy. BioRxiv. doi: 10.1101/2020.05.29.117531

NM Walker, G Kleer, K Misumi, R Vittal, N Sonenberg, VN Lama. (2020). MNK/eIF4E Ser209 Deletion Confers Protection in Murine Bleomycin Induced Lung Fibrosis Model. Am J Respir Crit Care Med.

Dana Pearl, Sakie Katsumura, Mehdi Amiri, Negar Tabatabaei, Xu Zhang, Valerie Vinette, Xinhe Pang, Shawn T Beug, Sung-Hoon Kim, Laura M Jones, Nathaniel Robichaud, Sang-Ging Ong, Jian-Jun Jia, Hamza Ali, Michel L Tremblay, Maritza Jaramillo, Tommy Alain, Masahiro Morita, Nahum Sonenberg, Soroush Tahmasebi (2020). 4E-BP–Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response. J Immunol. doi: 10.4049/jimmunol.1900538

Bin Xiao, Dongmei Zuo, Alison Hirukawa, Robert D Cardiff, Richard Lamb, Nahum Sonenberg, William J Muller (2020). Rheb1-independent activation of mTORC1 in mammary tumors occurs through activating mutations in mTOR. Cell Rep. doi: 10.1016/j.celrep.2020.107571

Yaser Atlasi, Seyed Mehdi Jafarnejad, Christos G Gkogkas, Michiel Vermeulen, Nahum Sonenberg, Hendrik G Stunnenberg (2020). The translational landscape of ground state pluripotency. Nat Commun. doi: 10.1038/s41467-020-15449-9

Thomas Gonatopoulos-Pournatzis, Rieko Niibori, Eric W Salter, Robert J Weatheritt, Brian Tsang, Shaghayegh Farhangmehr, Xinyi Liang, Ulrich Braunschweig, Jonathan Roth, Shen Zhang, Tyler Henderson, Eesha Sharma, Mathieu Quesnel-Vallieres, Jon Permanyer, Stefan Maier, John Georgiou, Manuel Irimia, Nahum Sonenberg, Julie D Forman-Kay, Anne-Claude Gingras, Graham L Collingridge, Melanie A Woodin, Sabine P Cordes, Benjamin J Blencowe (2020). Autism-misregulated eIF4G microexons control synaptic translation and higher order cognitive functions. Mol Cell. doi: 10.1016/j.molcel.2020.01.006

Cassandra C Areal, Ruifeng Cao, Nahum Sonenberg, Valérie Mongrain. (2020). Wakefulness/sleep architecture and electroencephalographic activity in mice lacking the translational repressor 4E-BP1 or 4E-BP2. Sleep. doi: 10.1093/sleep/zsz210

Hayley I Muendlein, Joseph Sarhan, Beiyun C Liu, Wilson M Connolly, Stephen A Schworer, Irina Smirnova, Amy Y Tang, Vladimir Ilyukha, Jodie Pietruska, Soroush Tahmasebi, Nahum Sonenberg, Alexei Degterev, Alexander Poltorak (2020). Constitutive interferon attenuates RIPK1/3-mediated cytokine translation. Cell Rep. doi: 10.1016/j.celrep.2019.12.073

Subhathirai Subramaniyan Parimalam, Simona Badilescu, Nahum Sonenberg, Rama Bhat, Muthukumaran Packirisamy (2019). Lab-on-a-chip for the development of pro-/anti-angiogenic nanomedicines to treat brain diseases. IJMS. doi: 10.3390/ijms20246126

D De Gregorio, J Popic, J Enns, L Posa, A Aguilar-Valles, N Sonenberg, G Gobbi (2019). S. 17.02 Lysergic acid diethylamide reverses anxious-like behaviour and modulates serotonergic neurotransmission in a chronic stress model. J. Euroneuro. doi: 10.1016/j.euroneuro.2019.09.042

Salil Saurav Pathak, Dong Liu, Tianbao Li, Nuria de Zavalia, Lei Zhu, Jin Li, Ramanujam Karthikeyan, Tommy Alain, Andrew C Liu, Kai-Florian Storch, Randal J Kaufman, Victor X Jin, Shimon Amir, Nahum Sonenberg, Ruifeng Cao (2019). The eIF2α kinase GCN2 modulates period and rhythmicity of the circadian clock by translational control of Atf4. Neuron. doi: 10.1016/j.neuron.2019.08.007

David Müller, Sauyeun Shin, Théo Goullet de Rugy, Rémi Samain, Romain Baer, Manon Strehaiano, Laia Masvidal-Sanz, Julie Guillermet-Guibert, Christine Jean, Yoshinori Tsukumo, Nahum Sonenberg, Frédéric Marion, Nicolas Guilbaud, Jean-Sébastien Hoffmann, Ola Larsson, Corinne Bousquet, Stéphane Pyronnet, Yvan Martineau. eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer. JCI Insight. doi: 10.1172/jci.insight.121951

Christopher R Starr, Cyril NA Nyankerh, Xiaoping Qi, Yang Hu, Oleg S Gorbatyuk, Nahum Sonenberg, Michael E Boulton, Marina S Gorbatyuk (2019). Role of translational attenuation in inherited retinal degeneration. IOVS. doi: 10.1167/iovs.19-27512

X Zhang, C Chapat, P Wang, S-H Kim, IF Karam, T Alain, SM Jafarnejad, L Yang, R Lin, N Sonenberg (2019). Translational control of the antiviral immune signaling by the cap-binding protein 4EHP. EJI.

Shane Wiebe, Anmol Nagpal, Vinh T Truong, Jeehyun Park, Agnieszka Skalecka, Alexander J He, Karine Gamache, Arkady Khoutorsky, Ilse Gantois, Nahum Sonenberg (2019). Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. PNAS. doi: 10.1073/pnas.190812611

Soroush Tahmasebi, Nahum Sonenberg, John WB Hershey, Michael B Mathews (2019). Protein synthesis and translational control: a historical perspective. Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a035584

Tae Hun Kim, Brian Tsang, Robert M Vernon, Nahum Sonenberg, Lewis E Kay, Julie D Forman-Kay (2019). Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. Science. doi: 10.1126/science.aax424

Amro H Mohammad, Sarah Assadian, Frédéric Couture, Karen J Lefebvre, Wissal El-Assaad, Veronique Barrès, Veronique Ouellet, Pierre-Luc Boulay, Jieyi Yang, Mathieu Latour, Luc Furic, William Muller, Nahum Sonenberg, Anne-Marie Mes-Masson, Fred Saad, Robert Day, Jose G Teodoro (2019). V-ATPase-associated prorenin receptor is upregulated in prostate cancer after PTEN loss. Oncotarget. doi: 10.18632/oncotarget.27075

Christopher Ryan Starr, Nahum Sonenberg, Marina S Gorbatyuk (2019). Restoring protein synthesis delays retinal degeneration. IOVS. (Abstract)

L Ranum, L Nguyen, F Montrasio, O Bardhi, S Guo, SK Tusi, K Nakamura, MB Coronel, N Sonenberg, J Grimm, T Zu (2019). Targeting ran proteins improves phenotypes in C9orf72 BAC ALS/FTD mice. J Neurochem. doi:

N Sonenberg, A Aguilar-Valles, A Skaleka, E Matta-Camacho, MJ Eslamizade, DD Gregorio, A Torres-Berrio, G Gobbi, J-C Lacaille (2019). Antidepressant effect of ketamine via the mTOR pathway and eEIF4E-dependent mRNA translation. J Neurochem. doi:

MK Cieplak-Rotowska, A Stelmachowska, MR Fabian, K Tamowski, M Dadlez, N Sonenberg, A Niedzwiecka (2019). HDX MS and pull-down analysis reveal the competition between human GW182 and tristetraprolin for binding to CNOT1. Eur. Biophys. J. doi:

Nathaniel Robichaud, Nahum Sonenberg, Davide Ruggero, Robert J Schneider (2019). Translational Control in Cancer. Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a032896

Olivier Le Bacquer, Kristell Combe, Véronique Patrac, Brian Ingram, Lydie Combaret, Dominique Dardevet, Christophe Montaurier, Jérôme Salles, Christophe Giraudet, Christelle Guillet, Nahum Sonenberg, Yves Boirie, Stéphane Walrand (2019). 4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia. J. Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12412

Masahiro Morita, Nadeem Siddiqui, Sakie Katsumura, Christopher Rouya, Ola Larsson, Takeshi Nagashima, Bahareh Hekmatnejad, Akinori Takahashi, Hiroshi Kiyonari, Mengwei Zang, René St-Arnaud, Yuichi Oike, Vincent Giguère, Ivan Topisirovic, Mariko Okada-Hatakeyama, Tadashi Yamamoto, Nahum Sonenberg (2019). Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis. PNAS. doi: 10.1073/pnas.1816023116

Zhiyong Wang, Xiaodong Feng, Alfredo A Molinolo, Daniel Martin, Lynn Vitale-Cross, Nijiro Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, Mara Gilardi, Michael Allevato, Victoria Wu, Dana J Steffen, Philip Tofilon, Nahum Sonenberg, Joseph Califano, Qianming Chen, Scott M Lippman, J Silvio Gutkind (2019). 4E-BP1 is a tumor suppressor protein reactivated by mTOR inhibition in head and neck cancer. Cancer Res. doi: 10.1158/0008-5472.CAN-18-1220

Seung Jae Jeong, Shinhye Park, Loi T Nguyen, Jungwon Hwang, Eun-Young Lee, Hoi-Khoanh Giong, Jeong-Soo Lee, Ina Yoon, Ji-Hyun Lee, Jong Hyun Kim, Hoi Kyoung Kim, Doyeun Kim, Won Suk Yang, Seon-Young Kim, Chan Yong Lee, Kweon Yu, Nahum Sonenberg, Myung Hee Kim, Sunghoon Kim (2019). A threonyl-tRNA synthetase-mediated translation initiation machinery. Nat Commun. doi: 10.1038/s41467-019-09086-0

Brian Tsang, Jason Arsenault, Robert M Vernon, Hong Lin, Nahum Sonenberg, Lu-Yang Wang, Alaji Bah, Julie D Forman-Kay (2019). Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. PNAS. doi: 10.1073/pnas.181438511

lse Gantois, Jelena Popic, Arkady Khoutorsky, Nahum Sonenberg (2019). Metformin for treatment of fragile X syndrome and other neurological disorders. Annu Rev Med. doi: 10.1146/annurev-med-081117-041238

Salim Megat, Pradipta R Ray, Jamie K Moy, Tzu-Fang Lou, Paulino Barragán-Iglesias, Yan Li, Grishma Pradhan, Andi Wanghzou, Ayesha Ahmad, Michael D Burton, Robert Y North, Patrick M Dougherty, Arkady Khoutorsky, Nahum Sonenberg, Kevin R Webster, Gregory Dussor, Zachary T Campbell, Theodore J Price (2019). Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. J Neurosci. doi: 10.1523/JNEUROSCI.2661-18.2018

Soroush Tahmasebi, Mehdi Amiri, Nahum Sonenberg (2019). Translational control in stem cells. Front. Genet. doi: 10.3389/fgene.2018.00709

Colin DH Ratcliffe, Nadeem Siddiqui, Paula P Coelho, Nancy Laterreur, Tumini N Cookey, Nahum Sonenberg, Morag Park (2019). HGF-induced migration depends on the PI(3,4,5)P3-binding microexon-spliced variant of the Arf6 exchange factor cytohesin-1. J Cell Biol. doi: 10.1083/jcb.201804106

Jerry Pelletier, Nahum Sonenberg (2019). The organizing principles of eukaryotic ribosome recruitment. Annu. Rev. Biochem. doi: 10.1146/annurev-biochem-013118-111042

Michael Mathews, Nahum Sonenberg, John WB Hershey (2019). Translation Mechanisms and Control: A Subject Collection from Cold Spring Harbor Perspectives in Medicine. CSHL Press.

Seyed Mehdi Jafarnejad, Sung-Hoon Kim, Nahum Sonenberg (2018). Aminoacylation of proteins: New targets for the old arsenal. Cell Metab. doi: 10.1016/j.cmet.2017.12.012

Jennifer Chu, Santiago Ramon y Cajal, Nahum Sonenberg, Jerry Pelletier (2018). Eukaryotic initiation factor 4F—sidestepping resistance mechanisms arising from expression heterogeneity. Curr Opin Genet Dev. doi: 10.1016/j.gde.2017.11.002

Seyed Mehdi Jafarnejad, Clement Chapat, Edna Matta-Camacho, Idit Anna Gelbart, Geoffrey G Hesketh, Meztli Arguello, Aitor Garzia, Sung-Hoon Kim, Jan Attig, Maayan Shapiro, Masahiro Morita, Arkady Khoutorsky, Tommy Alain, Christos, G Gkogkas, Noam Stern-Ginossar, Thomas Tuschl, Anne-Claude Gingras, Thomas F Duchaine, Nahum Sonenberg (2018). Translational control of ERK signaling through miRNA/4EHP-directed silencing. eLife. doi:1 0.7554/eLife.35034

Nathaniel Robichaud, Brian E Hsu, Roman Istomine, Fernando Alvarez, Julianna Blagih, Eric H Ma, Sebastian V Morales, David L Dai, Glenn Li, Margarita Souleimanova, Qianyu Guo, Sonia V Del Rincon, Wilson H Miller Jr, Santiago Ramon y Cajal, Morag Park, Russell G Jones, Ciriaco A Piccirillo, Peter M Siegel, Nahum Sonenberg (2018). Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils. PNAS. doi: 10.1073/pnas.1717439115

Mei Ding, Theodorus H Van der Kwast, Ravi N Vellanki, Warren D Foltz, Trevor D McKee, Nahum Sonenberg, Pier P Pandolfi, Marianne Koritzinsky, Bradly G Wouters (2018). The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer Hypoxia Tolerance via 4E-BP1 and 4E-BP2. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-17-0696

Dong Liu, Adam Stowie, Nuria de Zavalia, Tanya Leise, Salil Saurav Pathak, Lester R Drewes, Alec J Davidson, Shimon Amir, Nahum Sonenberg, Ruifeng Cao (2018). mTOR signalling in VIP neurons regulates circadian clock synchrony and olfaction. PNAS. doi: 10.1073/pnas.1721578115

Yumaine Chong, Natasha Saviuk, Brigitte Pie, Nathan Basisty, Ryan K Quinn, Birgit Schilling, Nahum Sonenberg, Ellis Cooper, A Pejmun Haghighi (2018). Removing 4E-BP enables synapses to refine without postsynaptic activity. Cell Rep. doi: 10.1016/j.celrep.2018.03.040

Santiago Ramon y Cajal, Josep Castellvi, Stefan Hümmer, Vicente Peg, Jerry Pelletier, Nahum Sonenberg (2018). Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene. doi: 10.1038/s41388-018-0152-0

Stephanie L Moon, Nahum Sonenberg, Roy Parker (2018). Neuronal regulation of eIF2α function in health and neurological disorders. Trends Mol. doi: 10.1016/j.molmed.2018.04.001

David Müller, Théo Goullet de Rugy, Sauyeun Shin, Rémi Samain, Romain Baer, Manon Strehaiano, Laia Masvidal-Sanz, Julie Guillermet-Guibert, Christine Jean, Yoshinori Tsukumo, Nahum Sonenberg, Frédéric Marion, Nicolas Guilbaud, Jean-Sébastien Hoffman, Ola Larsson, Corinne Bousquet, Stéphane Pyronnet, Yvan Martineau (2018). Translational control of DNA replication by 4E-BP1 in pancreatic cancer. Pancreatology. doi: 10.1016/j.pan.2018.05.326

Talin Ebrahimian, France Dierick, David Simon, Christophe Goncalves, Nahum Sonenberg, Sonia V Del Rincon, Stephanie Lehoux (2018). Inhibition of eIF4E Phosphorylation Regulates Plaque Composition Without Affecting Atherosclerosis Development. Atheroscler. Suppl. doi: 10.1016/j.atherosclerosissup.2018.04.275

Argel Aguilar-Valles, Nabila Haji, Danilo De Gregorio, Edna Matta-Camacho, Mohammad J Eslamizade, Jelena Popic, Vijendra Sharma, Ruifeng Cao, Christoph Rummel, Arnaud Tanti, Shane Wiebe, Nicolas Nuñez, Stefano Comai, Robert Nadon, Giamal Luheshi, Naguib Mechawar, Gustavo Turecki, Jean-Claude Lacaille, Gabriella Gobbi, Nahum Sonenberg (2018). Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nat Commun. doi: 10.1038/s41467-018-04883-5

Chadi Zakaria, Polen Sean, Huy-Dung Hoang, Louis-Phillipe Leroux, Margaret Watson, Samuel Tekeste Workenhe, Jaclyn Hearnden, Dana Pearl, Vinh Tai Truong, Nathaniel Robichaud, Akiko Yanagiya, Soroush Tahmasebi, Seyed Mehdi Jafarnejad, Jian-Jun Jia, Adrian Pelin, Jean-Simon Diallo, Fabrice Le Boeuf, John Cameron Bell, Karen Louise Mossman, Tyson Ernst Graber, Maritza Jaramillo, Nahum Sonenberg, Tommy Alain (2018). Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLoS Pathog. doi: 10.1371/journal.ppat.1007264

Kodai Machida, Tomoaki Shigeta, Yuki Yamamoto, Takuhiro Ito, Yuri Svitkin, Nahum Sonenberg, Hiroaki Imataka (2018). Dynamic interaction of poly(A)-binding protein with the ribosome. Sci Rep. doi: 10.1038/s41598-018-35753-1

Soroush Tahmasebi, Arkady Khoutorsky, Michael B Mathews, Nahum Sonenberg (2018). Translation deregulation in human disease. Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-018-0034-x

Michaël Cerezo, Ramdane Guemiri, Sabine Druillennec, Isabelle Girault, Hélène Malka-Mahieu, Shensi Shen, Delphine Allard, Sylvain Martineau, Caroline Welsch, Sandrine Agoussi, Charlène Estrada, Julien Adam, Cristina Libenciuc, Emilie Routier, Séverine Roy, Laurent Désaubry, Alexander M Eggermont, Nahum Sonenberg, Jean Yves Scoazec, Alain Eychène, Stéphan Vagner, Caroline Robert (2018). Translational control of tumor immune escape via the eIF4F–STAT1–PD-L1 axis in melanoma. Nat Med. doi: 10.1038/s41591-018-0217-1